Ethyl indole-2-carboxylate → Ethyl 3-[bis(4-methylphenyl)methyl]indole-2-carboxylate

HRID 442883Notes

Reaction equation

HRID 442883 reaction equation
[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6](O)[C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[NH:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[C:18]1[C:26]([O:28][CH2:29][CH3:30])=[O:27]>>[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[C:19]2[C:20]3[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:17][C:18]=2[C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 73125Ethyl indole-2-carboxylateHCID 2793564,4'-Dimethylbenzhydrol

Product 1

HCID 67595302Ethyl 3-[bis(4-methylphenyl)methyl]indole-2-carboxylateYield 97.6%

Procedure

Substantially the same procedure as in Reference Example 4 was repeated using 4,4'-dimethylbenzhydrol (11.8 g, 55.5 mmol) and ethyl indole-2-carboxylate (10.0 g, 52.9 mmol) to give 19.8 g (yield: 97%) of the title compound.

Sources & evidence

ORD record
ord-f6c911c226084e87baceacae440e27ed
Source dataset
uspto-grants-1999_04
Patent number
US05891902

Reaction notes

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