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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 442883Generated: October 26, 2026

Ethyl indole-2-carboxylate → Ethyl 3-[bis(4-methylphenyl)methyl]indole-2-carboxylate

https://huagongshe.com/reaction/442883

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-2-carboxylateHCID 73125—
Reactant4,4'-DimethylbenzhydrolHCID 279356—
ProductEthyl 3-[bis(4-methylphenyl)methyl]indole-2-carboxylateHCID 6759530297.6%

Reaction Steps

Substantially the same procedure as in Reference Example 4 was repeated using 4,4'-dimethylbenzhydrol (11.8 g, 55.5 mmol) and ethyl indole-2-carboxylate (10.0 g, 52.9 mmol) to give 19.8 g (yield: 97%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05891902
Source datasetuspto-grants-1999_04
ORD IDord-f6c911c226084e87baceacae440e27ed
Source noteuspto-grants-1999_04