Dimethyl Sulfoxide → 3-[3-(2-Methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde

HRID 442915Notes

Reaction equation

HRID 442915 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([O:12][C:13]1[CH:14]=[C:15]([CH:21]=[C:22]([CH3:24])[CH:23]=1)[O:16][CH2:17][CH2:18][CH2:19][OH:20])(=[O:11])=[O:10].C(N(CC)C(C)C)(C)C.CS(C)=O>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([O:12][C:13]1[CH:14]=[C:15]([CH:21]=[C:22]([CH3:24])[CH:23]=1)[O:16][CH2:17][CH2:18][CH:19]=[O:20])(=[O:11])=[O:10]

Participants

5

Reactant 3

HCID 679Dimethyl SulfoxideHCID 81531DiisopropylethylamineHCID 227224653-[3-(2-Methoxyphenylsulfonyloxy)-5-methylphenoxy]propanol

Product 1

HCID 227226443-[3-(2-Methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehydeYield 62%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

Sulfur trioxide pyridine complex (1.87 g, 11.7 mmol) was added portionwise over 15 min to a solution of 3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propanol (2.07 g, 5.9 mmol, as prepared in the preceding step), N,N-diisopropylethylamine (2.15 mL, 12.3 mmol), and anhydrous dimethyl sulfoxide (1.25 mL, 17.6 mmol) in anhydrous dichloromethane (14 mL) at 0° C. under a nitrogen atmosphere. The solution was stirred at 0° C. for 1 h, then the reaction was quenched with 5% aqueous citric acid (50 mL). The layers were separated, and the aqueous layer was extracted with dichloromethane (15 mL). The combined organic extracts were washed with 5% aqueous citric acid (50 mL), pH 7 buffer (40 mL) and brine (50 mL), dried over Na2SO4, filtered, and evaporated. The residual gold oil was purified by flash column chromatography (3:2 diethyl ether/hexane) to give the title compound (1.28 g, 62%) as a colorless oil. 1H-NMR (300 MHz, CDCl3) δ 9.82 (t, 1 H, J=1.5 Hz), 7.82 (dd, 1 H, J=1.7, 7.9 Hz), 7.62 (ddd, 1 H, J=1.8, 7.4, 8.4 Hz), 7.09 (dd, 1 H, J=0.8, 8.4 Hz), 7.02 (m, 1 H), 6.58 (br s, 1 H), 6.54 (br s, 1 H), 6.45 (t, 1 H, J=2 Hz), 4.18 (t, 2 H, J=6.1 Hz), 4.02 (s, 3 H), 2.85 (td, 2 H, J=1.5,6.1Hz), 2.24 (s, 3 H). Mass spectrum (MALDI-TOF, α-cyano-4-hydroxycinnamic acid matrix) calcd. for C17H18O6S: 373.1 (M+Na). Found: 373.0.

Workup

  1. customthe reaction was quenched with 5% aqueous citric acid (50 mL)
  2. customThe layers were separated
  3. extractionthe aqueous layer was extracted with dichloromethane (15 mL)
  4. washThe combined organic extracts were washed with 5% aqueous citric acid (50 mL), pH 7 buffer (40 mL) and brine (50 mL)
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. customevaporated
  8. customThe residual gold oil was purified by flash column chromatography (3:2 diethyl ether/hexane)

Sources & evidence

ORD record
ord-77d50448edb248c389e2c8a9d42fb965
Source dataset
uspto-grants-1999_04
Patent number
US05891909

Reaction notes

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