Dimethyl Sulfoxide → 3-[5-Methyl-3-(1-naphthalenylsulfonyloxy)phenoxy]propionaldehyde

HRID 442957Notes

Reaction equation

HRID 442957 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([O:13][S:14]([C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH:5]=[C:6]([CH:12]=1)[O:7][CH2:8][CH2:9][CH2:10][OH:11].C(N(CC)C(C)C)(C)C.CS(C)=O>ClCCl>[CH3:1][C:2]1[CH:3]=[C:4]([O:13][S:14]([C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH:5]=[C:6]([CH:12]=1)[O:7][CH2:8][CH2:9][CH:10]=[O:11]

Participants

5

Reactant 3

HCID 679Dimethyl SulfoxideHCID 81531DiisopropylethylamineHCID 542805743-[5-Methyl-3-(1-naphthalenylsulfonyloxy)phenoxy]propanol

Product 1

HCID 543837113-[5-Methyl-3-(1-naphthalenylsulfonyloxy)phenoxy]propionaldehydeYield 91.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Sulfur trioxide pyridine complex (800 mg, 5.0 mmol) was added to a solution of 3-[5-methyl-3-(1-naphthalenylsulfonyloxy)phenoxy]propanol (600 mg, 1.6 mmol), as prepared in the preceding step, N,N-diisopropylethylamine (0.7 mL, 5.5 mmol) and anhydrous dimethyl sulfoxide (0.4 mL, 5.6 mmol) in anhydrous dichloromethane (15 mL). The reaction mixture was stirred at ambient temperature for 1 hour and then quenched with 10% aqueous citric acid (60 mL). The mixture was extracted into dichloromethane (3×50 mL), and the dichloromethane solution was washed with 10% aqueous citric acid (40 mL) and dried over Na2SO4. After removing the solvent in vacuo, the residue was purified by flash column chromatography (dichloromethane) to give the title compound as a colorless oil (540 mg, 90%). 1H-NMR (300 MHz, CDCl3) δ 9.76 (s, 1H), 8.80 (d, J=8.6 Hz, 1H), 8.14 (d, J=7.7 Hz, 2H), 7.99 (d, J=8.1 Hz, 1H), 7.78 (t, J=8.1 Hz, 1H), 7.67 (t, J=8.1 Hz, 1H), 7.50 (t, J=7.8 Hz, 1H), 6.53 (s, 1H), 6.35 (s, 1H), 6.20 (s, 1H), 4.02 (t, J=6.1 Hz, 2H), 2.76 (t, J=6.1 Hz, 2H), 2.15 (s, 3H).

Workup

  1. customquenched with 10% aqueous citric acid (60 mL)
  2. extractionThe mixture was extracted into dichloromethane (3×50 mL)
  3. washthe dichloromethane solution was washed with 10% aqueous citric acid (40 mL)
  4. dry with materialdried over Na2SO4
  5. customAfter removing the solvent in vacuo
  6. customthe residue was purified by flash column chromatography (dichloromethane)

Sources & evidence

ORD record
ord-5d57fd0bc77a4714aef65fcac1171b9f
Source dataset
uspto-grants-1999_04
Patent number
US05891909

Reaction notes

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