Phenylglyoxylic Acid → 2-Oxo-2-phenylacetyl chloride
Reaction equation
[C:1]1([C:7](=[O:11])[C:8](O)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.COC(Cl)[Cl:15]>>[C:1]1([C:7](=[O:11])[C:8]([Cl:15])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Participants
3
Procedure
In a 50 mL-volume flask, 12.2 g of phenyl glyoxylic acid was placed, and then 9.26 g of dichloromethyl methyl ether was dropwise added at room temperature. The mixture was stirred at room temperature for 1 hour. The reaction mixture was placed under reduced pressure (62° C./2 torr) to give 13.4 g of phenylglyoxylic acid chloride. The obtained phenylglyoxylic acid chloride was dropwise added to a mixture of 7.86 g of phenol, 7.26 g of pyridine and 10 mL of toluene. The resulting mixture was stirred at 50° C. for 2 hours.
Workup
- customwas placed under reduced pressure (62° C./2 torr)
Sources & evidence
- ORD record
- ord-c5329d5d153542bd8729df4981c7f661
- Source dataset
- uspto-grants-1999_04
- Patent number
- US05892091
Reaction notes
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