2-Methoxyphenylacetic acid → 2-(5-Chloro-2-methoxyphenyl)acetic acid

Temperature

-15 °C

A flame dried three-necked 3-L round-bottomed flask, equipped with a septa, stirring bar, argon inlet, thermocouple and addition funnel capped with a septa, was vacuum/argon purged. The flask was charged with commercially available 2-methoxy phenylacetic acid (300 g, 1.81 mol) and anhydrous THF (2 L). The mixture was cooled to approximately -15° C. and stirred until the solution became homogeneous. Neat sulfuryl chloride (205 mL, 2.55 mol) was added dropwise via an additional funnel while stirring over an hour. The internal temperature was maintained below -5° C. (ranging between -15° and -5° C.). Immediately after the complete addition of sulfuryl chloride, HPLC analysis showed the reaction was complete. The reaction mixture was poured into cold water (16 L) with vigorous stirring. The resultant slurry was stirred for 3 hours and the white precipitate was collected by filtration, washed with water (2 L), air dried for about 24 h, and vacuum dried to afford 345.3 g (95% yield, 97% by HPLC) of the title compound as an off-white solid that was used without further purification in the next step.

1. customA flame dried three-necked 3-L round-bottomed flask, equipped with a septa
2. additionthermocouple and addition funnel
3. customcapped with a septa
4. custompurged
5. stirringstirred until the solution
6. stirringwhile stirring over an hour
7. temperatureThe internal temperature was maintained below -5° C. (ranging between -15° and -5° C.)
8. stirringThe resultant slurry was stirred for 3 hours
9. filtrationthe white precipitate was collected by filtration
10. washwashed with water (2 L), air
11. customdried for about 24 h
12. customvacuum dried

ORD record

ord-542764c8b8e64036ae4c5483b630a2fa

Source dataset

uspto-grants-1999_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05892106