反应详情

温度

0 °C

The product from Step C is dissolved in acetonitrile and cooled to 0° C. Triethyl phosphite (1 equivalent) and sodium iodide (1 equivalent) are added, and the reaction stirred at room temperature overnight. The reaction is quenched with ammonium chloride, and extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and concentrated to provide the title compound.

1. customThe reaction is quenched with ammonium chloride
2. extractionextracted with ethyl acetate
3. dry with materialThe organic phase is dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated