Hydrochloric Acid → HCID 21193350, compound

HRID 443295Notes

Reaction equation

HRID 443295 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:22][OH:23])([S:14][C:15]2[CH:16]=[C:17]([CH3:21])[CH:18]=[CH:19][CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>ClCCl>[ClH:24].[OH:23][CH2:22][C:11]1([S:14][C:15]2[CH:16]=[C:17]([CH3:21])[CH:18]=[CH:19][CH:20]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21193235HCID 21193235, compound

Product 1

HCID 21193350HCID 21193350, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

A solution of N-tert-butoxycarbonyl-4-hydroxymethyl-4-(3-tolylsulfanyl)piperidine (0.27 g) in dichloromethane (25 mL) at 0° C. was saturated with hydrogen chloride gas. The resultant solution was sealed with a rubber septum and stirred at 0° C. for one h. The product solution was concentrated under vacuum to provide the title compound.

Workup

  1. customat 0° C.
  2. concentrationThe product solution was concentrated under vacuum

Sources & evidence

ORD record
ord-54b6fd58868f44a6a584a30f43a63698
Source dataset
uspto-grants-1999_04
Patent number
US05891889

Reaction notes

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