HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperazinecarboxaldehyde → 1-[(2H)-1,3-benzoxathiol-5-yl methyl]-4-(1,3,4-thiadiazol-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Reactant | 5-chloromethyl-(2H)-1,3-benzoxathiole | HCID 23467107 | — |
| Reactant | 1-[(2H)-1,3-benzoxathiol-5-yl methyl]piperazine | HCID 70575074 | — |
| Product | 1-[(2H)-1,3-benzoxathiol-5-yl methyl]-4-(1,3,4-thiadiazol-2-yl)piperazine | HCID 70575084 | — |
Reaction Steps
The starting 1-[(2H)-1,3-benzoxathiol-5-yl methyl]piperazine, M.P. of its dihydrochloride: 275°-278° C., was prepared by hydrolysis with alcoholic potassium hydroxyde of the corresponding formyl derivative, raw oil itself prepared by condensing 5-chloromethyl-(2H)-1,3-benzoxathiole with an excess of 1-formyl piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04260610 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-e0fc7b312d8a4377bdcebbb675ba3ae1 |
| Source note | uspto-grants-1981_04 |