Hydroxyamine hydrochloride → HCID 85979144, compound

Participants

Reaction Steps

55.5 g Hydroxyamine hydrochloride is added to 53.6 g 3-chloro-1-phenyl-isoquinoline-4-aldehyde in 150 ml pyridine at 0° C. The resulting mixture is left to stand at room temperature for 2 hours. Then, successively, the solvent is removed in vacuo, the residue is partioned between water and toluene, the toluenic phase is dried and concentrated. 43.2 g 3-chloro-1-phenyl-isoquinoline-4-aldoxime having a melting point from 151° to 154° C. are obtained.

Provenance & Evidence