Hydroxyamine hydrochloride → HCID 85979144, compound

HRID 443381Notes

Reaction equation

HRID 443381 reaction equation
Cl.[OH:2][NH2:3].[Cl:4][C:5]1[N:6]=[C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:8]2[C:13]([C:14]=1[CH:15]=O)=[CH:12][CH:11]=[CH:10][CH:9]=2>N1C=CC=CC=1>[Cl:4][C:5]1[N:6]=[C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:8]2[C:13]([C:14]=1[CH:15]=[N:3][OH:2])=[CH:12][CH:11]=[CH:10][CH:9]=2

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 145672483-Chloro-1-phenylisoquinoline-4-carbaldehyde

Product 1

HCID 85979144HCID 85979144, compoundYield 76.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

55.5 g Hydroxyamine hydrochloride is added to 53.6 g 3-chloro-1-phenyl-isoquinoline-4-aldehyde in 150 ml pyridine at 0° C. The resulting mixture is left to stand at room temperature for 2 hours. Then, successively, the solvent is removed in vacuo, the residue is partioned between water and toluene, the toluenic phase is dried and concentrated. 43.2 g 3-chloro-1-phenyl-isoquinoline-4-aldoxime having a melting point from 151° to 154° C. are obtained.

Workup

  1. waitThe resulting mixture is left
  2. customThen, successively, the solvent is removed in vacuo
  3. customthe toluenic phase is dried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-67fdbe96f82243b9b429c60a8125bb5e
Source dataset
uspto-grants-1981_04
Patent number
US04260611

Reaction notes

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