Sodium Hydroxide → HCID 13369413, compound

HRID 443401Notes

Reaction equation

HRID 443401 reaction equation
[OH-].[Na+].[NH:3]([CH:10]1[C:15]2=[N:16][CH:17]=[C:18](C(O)=O)[C:19](=[O:20])[N:14]2[CH:13]([CH3:24])[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[H][H]>O>[NH:3]([CH:10]1[C:15]2=[N:16][CH:17]=[CH:18][C:19](=[O:20])[N:14]2[CH:13]([CH3:24])[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 13369414HCID 13369414, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13369413HCID 13369413, compoundYield 46.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 0.4 g. of sodium hydroxide in 10 ml. of water 1.0 g. (3.34 mmoles) of 9-anilino-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid is added. The solution is stirred for 5 hours in a hydrogen gas atmosphere at 70°-80° C. The reaction mixture is then cooled to room temperature, the precipitated crystals are filtered and washed with water. 0.4 g. (46.9%) of 9-anilino-6-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-4-one is obtained. Melting point: 160°-162° C. The product melts at 165°-167° C. after recrystallization from acetonitrile.

Workup

  1. filtrationthe precipitated crystals are filtered
  2. washwashed with water

Sources & evidence

ORD record
ord-57df64404abf47fe9cecb911d179ddd7
Source dataset
uspto-grants-1981_04
Patent number
US04260612

Reaction notes

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