Sodium Hydroxide → HCID 13369413, compound

Participants

Reaction Steps

To a solution of 0.4 g. of sodium hydroxide in 10 ml. of water 1.0 g. (3.34 mmoles) of 9-anilino-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid is added. The solution is stirred for 5 hours in a hydrogen gas atmosphere at 70°-80° C. The reaction mixture is then cooled to room temperature, the precipitated crystals are filtered and washed with water. 0.4 g. (46.9%) of 9-anilino-6-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-4-one is obtained. Melting point: 160°-162° C. The product melts at 165°-167° C. after recrystallization from acetonitrile.

Provenance & Evidence