HCID 15584879, compound → HCID 23467118, compound

HRID 443402Notes

Reaction equation

HRID 443402 reaction equation
[Br:1][CH:2]1[C:7]2=[N:8][CH:9]=[C:10](C(O)=O)[C:11](=[O:12])[N:6]2[CH:5]([CH3:16])[CH2:4][CH2:3]1>N1C=CC=CC=1>[Br-:1].[CH3:16][CH:5]1[N:6]2[C:11](=[O:12])[CH:10]=[CH:9][N:8]=[C:7]2[CH:2]([N+:6]2[CH:7]=[CH:2][CH:3]=[CH:4][CH:5]=2)[CH2:3][CH2:4]1

Participants

3

Reactant 1

HCID 15584879HCID 15584879, compound

Product 1

HCID 23467118HCID 23467118, compoundYield 66.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1.0 g. (3.48 mmoles) of 9-bromo-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid is dissolved in 4 ml. of pyridine and the solution is allowed to stand for 3 days at room temperature. The precipitated crystals are filtered and washed with chloroform. 0.75 g. (66.9%) of 1-(6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-9-yl)-pyridinium bromide is obtained. Melting point: 250°-252° C. After recrystallization twice from methanol the melting point is increased to 270°-272° C.

Workup

  1. filtrationThe precipitated crystals are filtered
  2. washwashed with chloroform

Sources & evidence

ORD record
ord-a2fd933227144d26a699b89c3edbf4ee
Source dataset
uspto-grants-1981_04
Patent number
US04260612

Reaction notes

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