1-Methyl-4-piperidone → HCID 23467206, compound

HRID 443429Notes

Reaction equation

HRID 443429 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][NH:11]2)[OH:9])=[CH:4][CH:3]=1.[CH3:16][N:17]1[CH2:22][CH2:21][C:20](=O)[CH2:19][CH2:18]1>>[CH3:16][N:17]1[CH2:22][CH2:21][C:20]2([N:11]3[CH2:12][CH2:13][CH2:14][CH2:15][CH:10]3[CH:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[O:9]2)[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 740491-Methyl-4-piperidoneHCID 23467219HCID 23467219, compound

Product 1

HCID 23467206HCID 23467206, compound

Procedure

Utilizing the procedure described in Example 1 above, alpha-(4-chlorophenyl)-2-piperidinemethanol (10 g) is reacted with 1-methyl-4-piperidone (7 g) to yield hexahydro-1'-methyl-1-(4-chlorophenyl)spiro[3H-oxazolo[3,4-a]pyridine-3,4'-piperidine]; mp 122°-124° C., after chromatography over silica gel with ethyl acetate.

Sources & evidence

ORD record
ord-32cd5657742340b0ac33f6776ae9486d
Source dataset
uspto-grants-1981_04
Patent number
US04260623

Reaction notes

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