Propionic Acid → HCID 13018768, compound

HRID 443459Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[NH2:9][CH2:10][CH2:11][CH2:12]O.[C:14]([OH:18])(=O)[CH2:15][CH3:16]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:12][CH2:11][CH2:10][NH:9][C:14](=[O:18])[CH2:15][CH3:16])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 1032Propionic Acid

HCID 78114-Methylbenzenethiol

HCID 90863-Amino-1-propanol

Product 1

HCID 13018768HCID 13018768, compound

Procedure

The experiment of Example 1A was repeated in all essential details except that p-thiocresol, 3-aminopropanol and propionic acid in equimolar amounts were used as the reactants. There was obtained N-[3-(p-methylphenylthio)-propyl]propionamide, m.p. 55.5°-56.5° C., designated P-2142. The nmr spectrum was consistent with the proposed structure. P-2142 was generally ineffective for controlling the growth of seven species of bacteria but was effective (MIC-100-500) for controlling the growth of four species of fungi.

Sources & evidence

ORD record: ord-5416154be46b428782113a2a6105c7bb
Source dataset: uspto-grants-1981_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04260634

Reaction notes

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