反应详情

To 35 ml of carbon tetrachloride are added 2.81 g (10.0 mmol) of (R)-2-(4-trifluoromethylphenylamino)-3-methylbutanoic acid and 1.33 g (9.96 mmol) of N-chlorosuccinimide, and the mixture is heated to reflux for 1 hour. The mixture is worked up by partition between ether/water. The layers are separated and the aqueous phase is extracted with ether (2×). The combined organic extracts are washed with water and with brine, dried over magnesium sulfate, filtered and evaporated, giving (R)-2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid.

1. temperaturethe mixture is heated
2. temperatureto reflux for 1 hour
3. customby partition between ether/water
4. customThe layers are separated
5. extractionthe aqueous phase is extracted with ether (2×)
6. washThe combined organic extracts are washed with water and with brine
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. customevaporated