HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dicyclohexylcarbodiimide → (S)-alpha-cyano-3-phenoxybenzyl (R)-2-(4-trifluoromethylphenylamino)-3-methylbutanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Edukt | (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile | HCID 9837437 | — |
| Edukt | N-[4-(trifluoromethyl)phenyl]-D-valine | HCID 13388455 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Lösungsmittel | Chloroform | HCID 6212 | — |
| Produkt | (S)-alpha-cyano-3-phenoxybenzyl (R)-2-(4-trifluoromethylphenylamino)-3-methylbutanoate | HCID 13388459 | — |
Reaktionsschritte
Following the procedure of Example 8, (R)-2-(4-trifluoromethylphenylamino)-3-methylbutanoic acid and (S)-α-cyano-3-phenoxybenzyl alcohol are combined, in the presence of 4-dimethylaminopyridine and dicyclohexylcarbodiimide, to yield (S)-α-cyano-3-phenoxybenzyl (R)-2-(4-trifluoromethylphenylamino)-3-methylbutanoate, specific rotation=+62.1° (c=9 mg/ml in CHCl3).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04260633 |
| Quelldatensatz | uspto-grants-1981_04 |
| ORD ID | ord-0b984214d07c4c3ea77a5a7accb41c30 |
| Quellennotiz | uspto-grants-1981_04 |