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HRID443468

反应详情

EQUATION

反应方程式

HRID 443468 的结构方程式

REACTANTS

反应物

3
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：N#C[C@@H](O)c1cccc(Oc2ccccc2)c1
HCID9837437

(S)-2-Hydroxy-2-(3-phenoxyphenyl)acetonitrile

C14H11NO2

结构：CC(C)[C@@H](Nc1ccc(C(F)(F)F)cc1)C(=O)O
HCID13388455

N-[4-(Trifluoromethyl)phenyl]-D-valine

C12H14F3NO2

PRODUCTS

生成物

1
结构：CC(C)[C@@H](Nc1ccc(C(F)(F)F)cc1)C(=O)O[C@H](C#N)c1cccc(Oc2ccccc2)c1
HCID13388459

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Following the procedure of Example 8, (R)-2-(4-trifluoromethylphenylamino)-3-methylbutanoic acid and (S)-α-cyano-3-phenoxybenzyl alcohol are combined, in the presence of 4-dimethylaminopyridine and dicyclohexylcarbodiimide, to yield (S)-α-cyano-3-phenoxybenzyl (R)-2-(4-trifluoromethylphenylamino)-3-methylbutanoate, specific rotation=+62.1° (c=9 mg/ml in CHCl3).