反应详情

A mixture of 2.3 g. of 3-hydrazino-6-[3-(trifluoromethyl)phenyl]pyridazine, 188 g. of ethyl glycolate and 40 ml. of n-butyl alcohol is heated at reflux temperature for 18 hours. The mixture is evaporated in vacuo. To the residue is added dichloromethane and hexane. The mixture is filtered to give 2.0 g. of cream colored crystals. Recrystallization from ethyl acetate gives the product of the Example as off-white crystals, m.p. 224°-226° C.

1. additionA mixture of 2.3 g
2. temperatureat reflux temperature for 18 hours
3. customThe mixture is evaporated in vacuo
4. additionTo the residue is added dichloromethane and hexane
5. filtrationThe mixture is filtered
6. customto give 2.0 g
7. customRecrystallization from ethyl acetate
8. customgives the product of the Example as off-white crystals, m.p. 224°-226° C.