HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 3-(Hydroxymethyl)-6-[3-(trifluoromethyl)-phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 3-(Chloromethyl)-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine | HCID 12726862 | — |
| Catalyst | Silver Nitrate | HCID 24470 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(Hydroxymethyl)-6-[3-(trifluoromethyl)-phenyl]-1,2,4-triazolo[4,3-b]pyridazine | HCID 23467566 | — |
Reaction Steps
A 1.0 g. sample of 3-(chloromethyl)-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine is heated (50°-60° C.) in a mixture of acetone and water in the presence of silver nitrate. The mixture is filtered and the filtrate concentrated to give the product of the Example.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04260755 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-b09295d1f68e49e99079e8df9b155206 |
| Source note | uspto-grants-1981_04 |