4-Amino-1,2,4-triazole → 8-(3-Thienyl)-1,2,4-triazolo[4,3-b]pyridazine

HRID 443519Notes

Reaction equation

HRID 443519 reaction equation
C[N:2](C)[CH:3]=[CH:4][C:5]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)=O.N[N:14]1[CH:18]=[N:17][N:16]=[CH:15]1>C1(C)C(C)=CC=CC=1>[S:9]1[CH:10]=[CH:11][C:7]([C:5]2[C:18]3[N:14]([CH:15]=[N:16][N:17]=3)[N:2]=[CH:3][CH:4]=2)=[CH:8]1

Participants

4

Reactant 2

HCID 114324-Amino-1,2,4-triazoleHCID 5964663-Dimethylamino-1-thien-3-ylpropen-1-one

Product 1

HCID 234675938-(3-Thienyl)-1,2,4-triazolo[4,3-b]pyridazine

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

As for Example 16, a mixture of 3-dimethylamino-1-(3-thienyl)-2-propen-1-one, 4-amino-1,2,4-triazole and xylene is refluxed for 16 hours to give the product of the Example.

Workup

  1. temperatureis refluxed for 16 hours
  2. customto give the product of the Example

Sources & evidence

ORD record
ord-cca759562e854a6ca181c33379774f96
Source dataset
uspto-grants-1981_04
Patent number
US04260756

Reaction notes

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