Diethyl Ether → HCID 13243717, compound

HRID 443620Notes

Reaction equation

HRID 443620 reaction equation
[C:1]1([CH2:7][CH2:8]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Mg].[CH3:11][C:12]([C:16]1[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[C:18]([O:24][CH3:25])[CH:17]=1)([CH3:15])[C:13]#N.CC[O:28]CC>>[CH3:15][C:12]([C:16]1[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[C:18]([O:24][CH3:25])[CH:17]=1)([C:13](=[O:28])[CH2:8][CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:11]

Participants

5

Reactant 4

HCID 3283Diethyl Ether2×HCID 7666Phenethyl bromideHCID 5462224MagnesiumHCID 97942622-(3,5-dimethoxyphenyl)-2-methylpropanenitrile

Product 1

HCID 13243717HCID 13243717, compound

Procedure

To a solution of the Grignard reagent prepared from 2-phenylbromoethane (5.5 g.), magnesium (0.8 g.) and dry ether (60 ml.) is added a solution of 2-methyl-2-(3,5-dimethoxyphenyl)propionitrile (2.75 g.) in dry ether (20 ml.). The ether is distilled off and replaced by dry benzene (50 ml.) and the mixture refluxed for 48 hours. It is then decomposed by careful treatment with dilute sulfuric acid and heated on a steam bath for one hour. The mixture is then extracted with ether, the extract dried (MgSO4) and concentrated to an oil. Distillation of the oil in vacuo affords 2-methyl-2-(3,5-dimethoxyphenyl)-5-phenyl-3-pentanone; b.p. 168° C./0.2 mm. (Yield: 2.32 g., 60%)

Workup

  1. distillationThe ether is distilled off
  2. temperaturethe mixture refluxed for 48 hours
  3. temperatureheated on a steam bath for one hour
  4. extractionThe mixture is then extracted with ether
  5. dry with materialthe extract dried (MgSO4)
  6. concentrationconcentrated to an oil
  7. distillationDistillation of the oil in vacuo

Sources & evidence

ORD record
ord-428d04698f8043948a380f1185095919
Source dataset
uspto-grants-1981_04
Patent number
US04260764

Reaction notes

Loading…