Hydrochloric Acid → HCID 23468286, compound

HRID 443634Notes

Reaction equation

HRID 443634 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:29]=[CH:28][C:22]([C:23]([O:25]CC)=[O:24])=[CH:21][CH:20]=1.[OH-].[K+].C(O)C.Cl>O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:29]=[CH:28][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 23468284HCID 23468284, compound

Product 1

HCID 23468286HCID 23468286, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 4.8 g. of ethyl p-{[6-(2-naphthyloxy)hexyl]amino}benzoate and 4.8 g. of potassium hydroxide in 100 ml. of 95% ethanol is refluxed for 3 hours. The solution is cooled, diluted with water and acidified with concentrated hydrochloric acid. The mixture is filtered and the solid washed with ethanol and water and recrystallized from ether-methylene chloride and acetone to give crystals, m.p. 157°-159° C.

Workup

  1. temperatureThe solution is cooled
  2. filtrationThe mixture is filtered
  3. washthe solid washed with ethanol and water
  4. customrecrystallized from ether-methylene chloride and acetone
  5. customto give crystals, m.p. 157°-159° C.

Sources & evidence

ORD record
ord-b6675380f51e4d5bb59b6909a667a3ef
Source dataset
uspto-grants-1981_04
Patent number
US04260816

Reaction notes

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