Hydrochloric Acid → HCID 23468289, compound

HRID 443640Notes

Reaction equation

HRID 443640 reaction equation
[C:1]1([O:11][CH2:12][CH2:13][NH:14][C:15]2[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[OH-].[K+].C(O)C.Cl>O>[C:1]1([O:11][CH2:12][CH2:13][NH:14][C:15]2[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:24][CH:25]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 23468280HCID 23468280, compound

Product 1

HCID 23468289HCID 23468289, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 12 g. of ethyl p-[2-(1-naphthyloxy)ethylamino]benzoate and 15.8 g. of potassium hydroxide in 100 ml. of 95% ethanol is refluxed for 3 hours. The solution is diluted with 75 ml. of water and acidified with concentrated hydrochloric acid. The solid is filtered, washed with 50% ethanol and with water. Recrystallization from ethanol gives the product as crystals, m.p. 193°-194° C.

Workup

  1. additionThe solution is diluted with 75 ml
  2. filtrationThe solid is filtered
  3. washwashed with 50% ethanol and with water
  4. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-27a7edbe8b47478e9005aa0527ee85ef
Source dataset
uspto-grants-1981_04
Patent number
US04260816

Reaction notes

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