反应详情

A mixture of 3.0 g. of ethyl p-{[2-(2-naphthyloxy)ethyl]amino}benzoate, and 3.0 g. of potassium hydroxide in 200 ml. of ethanol-water (95:5) is refluxed for 3 hours. The mixture is diluted with 100 ml. of water and brought to pH 6.0 with concentrated hydrochloric acid. The mixture is filtered and the solid washed with 50 ml. of water and 20 ml. of cold ethanol-water (4:1) to give the product, m.p. 208°-211° C.

1. additionA mixture of 3.0 g
2. additionThe mixture is diluted with 100 ml
3. filtrationThe mixture is filtered
4. washthe solid washed with 50 ml
5. customof cold ethanol-water (4:1) to give the product, m.p. 208°-211° C.