Potassium Hydroxide → HCID 23468292, compound

HRID 443647Notes

Reaction equation

HRID 443647 reaction equation
FC(F)(F)C([N:5]([CH2:17][CH2:18][O:19][C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23]([C:30]#[N:31])=[CH:22][CH:21]=1)[C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12]CC)=[O:11])=[CH:8][CH:7]=1)=O.[OH-].[K+]>C(O)C>[C:30]([C:23]1[C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:20]([O:19][CH2:18][CH2:17][NH:5][C:6]2[CH:7]=[CH:8][C:9]([C:10]([OH:12])=[O:11])=[CH:15][CH:16]=2)=[CH:21][CH:22]=1)#[N:31]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 23468304HCID 23468304, compound

Product 1

HCID 23468292HCID 23468292, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4.3 g. of ethyl 4-[N-trifluoroacetyl-2-(4-cyano-1-naphthyloxy)ethylamino]benzoate and 4.3 g. of potassium hydroxide in 100 ml. of 95% ethanol is refluxed for 3 hours. After cooling, diluting with 100 ml. of water and acidification to pH 4 with concentrated hydrochloric acid, the white solid is collected, washed with water and dried, m.p. 254°-256° C.

Workup

  1. temperatureAfter cooling
  2. additiondiluting with 100 ml
  3. customof water and acidification to pH 4 with concentrated hydrochloric acid, the white solid is collected
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-229415c02eb44e5784f0eab33a3815b6
Source dataset
uspto-grants-1981_04
Patent number
US04260816

Reaction notes

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