反应详情

A solution of 12.54 g. of 2-(1-naphthyloxy)ethyl bromide and 16.5 g. of ethyl anthranilate in 50 ml. of hexamethylphosphoramide are heated at 110° for 18 hours. After cooling and diluting with water, the mixture is extracted twice with 200 ml. of ether. The combined ether extracts are washed with water, dried and evaporated to a brown oil. The oil is dissolved in 60 ml. of ethanol and chilled in an ice-bath yielding a beige solid which is recrystallized from 100 ml. of ethanol affording pale yellow crystals, m.p. 81°-83° C.

1. temperatureAfter cooling
2. extractionthe mixture is extracted twice with 200 ml
3. washThe combined ether extracts are washed with water
4. customdried
5. customevaporated to a brown oil
6. dissolutionThe oil is dissolved in 60 ml
7. temperatureof ethanol and chilled in an ice-bath
8. customyielding a beige solid which
9. customis recrystallized from 100 ml