Dimethylamine → 2-Chloro-N,N-dimethylquinazolin-4-amine

HRID 44371Notes

Reaction equation

HRID 44371 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][NH:14][CH3:15]>>[Cl:1][C:2]1[N:11]=[C:10]([N:14]([CH3:15])[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 2528862,4-Dichloroquinazoline

Product 1

HCID 126843422-Chloro-N,N-dimethylquinazolin-4-amine

Procedure

Prepared as in Example 38 from 2,4-dichloroquinazoline and dimethylamine. 1H NMR (400 MHz, CDCl3) δ3.42 (s, 6H), 7.42-7.39 (m, 1H), 7.72-7.70 (m, 1H), 7.79-7.77 (m, 1H), 8.03-8.01 (m, 1H). MS 208 (MH+).

Sources & evidence

ORD record
ord-48760e7dcf094b8ea1571d069c9b4819
Source dataset
uspto-grants-2013_09
Patent number
US08541421B2

Reaction notes

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