反应详情

Dimethyl 3-(m-tolyl)-4,5-isothiazoledicarboxylate (14.03 g, 0.0548 mol) was hydrolyzed in NaOH (10.96 g, 0.274 mol) and 50 ml H2O for 0.5 hours at reflux. Acidification with HCl, extraction with ether and recrystallization gave a light yellow solid, m.p. 166.5°-167° with decomposition.

1. extractionAcidification with HCl, extraction
2. customwith ether and recrystallization
3. customgave a light yellow solid, m.p. 166.5°-167° with decomposition