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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 443710Generated: October 30, 2026

Sodium Hydroxide → 3-(m-Tolyl)-4,5-Isothiazoledicarboxylic Acid

https://huagongshe.com/reaction/443710

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantDimethyl 3-(m-Tolyl)-4,5-IsothiazoledicarboxylateHCID 12437411—
SolventWaterHCID 962—
Product3-(m-Tolyl)-4,5-Isothiazoledicarboxylic AcidHCID 12437431—

Reaction Steps

Dimethyl 3-(m-tolyl)-4,5-isothiazoledicarboxylate (14.03 g, 0.0548 mol) was hydrolyzed in NaOH (10.96 g, 0.274 mol) and 50 ml H2O for 0.5 hours at reflux. Acidification with HCl, extraction with ether and recrystallization gave a light yellow solid, m.p. 166.5°-167° with decomposition.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04261728
Source datasetuspto-grants-1981_04
ORD IDord-dd52ac546ced459db11de6b8fb612708
Source noteuspto-grants-1981_04