Methanol → HCID 23465074, compound

HRID 443713Notes

Reaction equation

HRID 443713 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[C:13]([C:14](Cl)=[O:15])=[CH:12][S:11][N:10]=2)[CH:4]=1.[CH3:19][OH:20]>>[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[C:13]([C:14]([O:20][CH3:19])=[O:15])=[CH:12][S:11][N:10]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 23465058HCID 23465058, compound

Product 1

HCID 23465074HCID 23465074, compound

Procedure

A solution of 2.92 g (0.010 mol) of 3-(α,α,α-trifluoro-m-tolyl)-4-isothiazolecarbonyl chloride prepared as in Example 29 and 10 ml of methanol was held at reflux for 0.5 hours and was concentrated under vacuum to 80° (0.3 torr) to 2.72 g of oil, nD23.4° =1.5404.

Workup

  1. temperatureat reflux for 0.5 hours
  2. concentrationwas concentrated under vacuum to 80° (0.3 torr) to 2.72 g of oil, nD23
  3. custom4° =1.5404

Sources & evidence

ORD record
ord-75d4a8235cce4b23b0d55fc9d92fe0fa
Source dataset
uspto-grants-1981_04
Patent number
US04261728

Reaction notes

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