反应详情

Eighty grams (0.43 mole) of cyanuric chloride is dissolved in 800 ml. of acetone, cooled to less than 10° C. and then one liter of water is added followed by 120 g. (0.96 mole) of 3-azabicyclo[3.2.2]nonane. After 2 hours the reaction is allowed to warm to room temperature and after a further 2 hours 35 g. (0.87 mole) of NaOH in 200 ml. of water is added over 2 hours. The reaction is then stirred for one hour and is then heated to reflux for a further one hour. Dilution with 2 l. of water gives a white precipitate which is filtered off and washed with water. The precipitate is then dissolved in one liter of chloroform and the aqueous solution separated. The aqueous solution is extracted with chloroform, the combined chloroform extracts washed with water, dried over magnesium sulfate and filtered through Magnesol®. The Magnesol® is then washed with one liter of chloroform, the solvent removed in vacuo, and the residue recrystallized from dichloromethane-hexanes giving 120 g. of colorless prisms, m.p. 195°-200° C.

1. temperatureis then heated
2. temperatureto reflux for a further one hour
3. filtrationis filtered off
4. washwashed with water
5. dissolutionThe precipitate is then dissolved in one liter of chloroform
6. customthe aqueous solution separated
7. extractionThe aqueous solution is extracted with chloroform
8. washthe combined chloroform extracts washed with water
9. dry with materialdried over magnesium sulfate
10. filtrationfiltered through Magnesol®
11. washThe Magnesol® is then washed with one liter of chloroform
12. customthe solvent removed in vacuo
13. customthe residue recrystallized from dichloromethane-hexanes giving 120 g