1,2,3,4-Tetrahydroisoquinoline → HCID 587557, compound

HRID 443820Notes

Reaction equation

HRID 443820 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][NH:12]1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:12]1[CH2:13][CH2:14][C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11]1)=[O:5]

Participants

4

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 691102-Chlorobenzoyl chloride

Product 1

HCID 587557HCID 587557, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

26.08 g of 2-chlorobenzoyl chloride were reacted with 44.33 g (0.6 mol) of 1,2,3,4-tetrahydroisoquinoline in chloroform overnight, whilst stirring. After the chloroform had been driven off, the resulting solid was recrystallised from isopropyl alcohol.

Workup

  1. customthe resulting solid was recrystallised from isopropyl alcohol

Sources & evidence

ORD record
ord-3e8cba2760f1408c8aaee1421dc556d0
Source dataset
uspto-grants-1981_04
Patent number
US04261998

Reaction notes

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