HCID 178488043, compound → HCID 178524063, compound

HRID 443822Notes

Reaction equation

HRID 443822 reaction equation
C[O:2][C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:7]3[C:6](=[O:19])[C:5]=2[CH:4]=1>Br.C(O)(=O)C.O>[OH:2][C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:7]3[C:6](=[O:19])[C:5]=2[CH:4]=1

Participants

5

Reactant 1

HCID 178488043HCID 178488043, compound

Product 1

HCID 178524063HCID 178524063, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolventHCID 962WaterSolvent

Procedure

A suspension of 4,9-dihydro-7-methoxy-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid (2.0 g; 0.0077 mole) in 48% hydrobromic acid (30 ml) and glacial acetic acid (50 ml) is refluxed for 23 hrs. The mixture is cooled and then diluted with water (25 ml). The product, which precipitates out, is collected by filtration and recrystallized from DMF-Ether (1:1, 90 ml). Yield 1.1 g; mp 285°-286° C. (d).

Workup

  1. temperatureis refluxed for 23 hrs
  2. temperatureThe mixture is cooled
  3. customThe product, which precipitates out
  4. filtrationis collected by filtration
  5. customrecrystallized from DMF-Ether (1:1, 90 ml)

Sources & evidence

ORD record
ord-18fa4349312740089f5bb05920fe843a
Source dataset
uspto-grants-1981_04
Patent number
US04261996

Reaction notes

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