Hydrogen Bromide → HCID 178524064, compound

HRID 443823Notes

Reaction equation

HRID 443823 reaction equation
C[O:2][C:3]1[C:12]2[NH:11][C:10]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:9]3[C:8](=[O:19])[C:7]=2[CH:6]=[CH:5][CH:4]=1.Br>C(O)(=O)C>[OH:2][C:3]1[C:12]2[NH:11][C:10]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:9]3[C:8](=[O:19])[C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 178488821HCID 178488821, compound

Product 1

HCID 178524064HCID 178524064, compoundYield 76.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

From 4,9-dihydro-5-methoxy-9-oxo-pyrazolo[5,1-b]-quinazoline-2-carboxylic acid (1.04 g), 48% hydrobromic acid (25 ml) and acetic acid (25 ml), following the procedure of Example 3, there is obtained the desired product (0.75 g) as the quarter hydrate. mp 326°-330° C.

Sources & evidence

ORD record
ord-dc2511dab781464eb537ad4dc6b72c80
Source dataset
uspto-grants-1981_04
Patent number
US04261996

Reaction notes

Loading…