Hydrochloric Acid → HCID 178504592, compound

HRID 443824Notes

Reaction equation

HRID 443824 reaction equation
[CH3:1][S:2][C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:7]3[C:6](=[O:19])[C:5]=2[CH:4]=1.[OH-].[Na+].I([O-])(=O)(=O)=[O:23].[Na+].Cl>O>[CH3:1][S:2]([C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:7]3[C:6](=[O:19])[C:5]=2[CH:4]=1)=[O:23]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23667635Sodium periodateHCID 178503101HCID 178503101, compound

Product 1

HCID 178504592HCID 178504592, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 4,9-dihydro-7-methylthio-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid (5.5 g; 0.02 mole) and 1(N) sodium hydroxide solution (25 ml) in water (500 ml) is chilled to 12° and a solution of sodium metaperiodate (4.28 g, 0.02 mole) in water (150 ml) is added. The reaction mixture is stirred at room temperature for 4 hrs and the resulting solution is cooled and treated with 1(N) HCl (30 ml). The greenish precipitate is filtered, washed and recrystallized from DMF-methanol. Yield 4.4 g; mp 285°-90° (d).

Workup

  1. temperatureis chilled to 12°
  2. temperaturethe resulting solution is cooled
  3. filtrationThe greenish precipitate is filtered
  4. washwashed
  5. customrecrystallized from DMF-methanol

Sources & evidence

ORD record
ord-9a7449646024456db8a16e732cd68bb7
Source dataset
uspto-grants-1981_04
Patent number
US04261996

Reaction notes

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