Sulfuric Acid → HCID 2732129, compound

HRID 443870Notes

Reaction equation

HRID 443870 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH:9]([CH2:13][C:14]#[N:15])[CH2:10][C:11]#N.[OH-:16].[NH4+:17].S(=O)(=O)(O)[OH:19]>O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH:9]([CH2:13][C:14]([NH2:15])=[O:19])[CH2:10][C:11]([NH2:17])=[O:16]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 13034522HCID 13034522, compound

Product 1

HCID 2732129HCID 2732129, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Twelve and three-tenths (12.3) of 3-(2,6-dichlorophenyl)glutaronitrile, prepared according to Preparation A, Part 1, is dissolved in a mixture of 70 ml of concentrated sulfuric acid and 3 ml of water. This solution is allowed to stand for 2 days at room temperature and then poured over crushed ice and is neutralized with ammonium hydroxide. The solid precipitate is collected, washed with water and dried under vacuum to give 13.8 g of 3-(2,6-dichlorophenyl)glutaramide, mp 221°-225°.

Workup

  1. customaccording to Preparation A, Part 1
  2. additionpoured
  3. customover crushed ice
  4. customThe solid precipitate is collected
  5. washwashed with water
  6. customdried under vacuum

Sources & evidence

ORD record
ord-aa5817d62c9447f8b328ed0b1fd1f86b
Source dataset
uspto-grants-1981_04
Patent number
US04261995

Reaction notes

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