Ammonia → HCID 12892044, compound

HRID 443896Notes

Reaction equation

HRID 443896 reaction equation
[N+:1]([C:4]1[C:9]2[N:10]3[CH2:15][CH2:14][N:13]=[C:11]3[S:12][C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-])=O.N.[H][H]>[Pt].CO>[N:13]1[CH2:14][CH2:15][N:10]2[C:9]3=[C:4]([NH2:1])[CH:5]=[CH:6][CH:7]=[C:8]3[S:12][C:11]=12

Participants

6

Reactant 3

HCID 222AmmoniaHCID 12891974HCID 12891974, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12892044HCID 12892044, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5.5 parts of 2,3-dihydro-5-nitroimidazo[2,1-b]benzothiazole and 160 parts of methanol, saturated with ammonia is hydrogenated at normal pressure and at room temperature with 2 parts of platinum-on-charcoal catalyst 5%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is crystallized from 1-butanol. The product is filtered off and dried, yielding 3 parts of 2,3-dihydroimidazo[2,1-b]benzothiazol-5-amine; mp. 229.2° C.

Workup

  1. filtrationthe catalyst is filtered off
  2. customthe filtrate is evaporated
  3. customThe residue is crystallized from 1-butanol
  4. filtrationThe product is filtered off
  5. customdried

Sources & evidence

ORD record
ord-5a0b6e6789414f4d99798cc5e4ba5d47
Source dataset
uspto-grants-1981_04
Patent number
US04262004

Reaction notes

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