Acetic Acid → HCID 12873988, compound

HRID 443904Notes

Reaction equation

HRID 443904 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:8]3[CH:9]=[C:10]([NH2:13])[CH:11]=[CH:12][C:7]=3[S:6][C:5]=12.C(O)(=O)C.[O-:18][C:19]#[N:20].[K+].[OH-].[NH4+]>O>[N:1]1[CH2:2][CH2:3][N:4]2[C:8]3[CH:9]=[C:10]([NH:13][C:19]([NH2:20])=[O:18])[CH:11]=[CH:12][C:7]=3[S:6][C:5]=12

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 14923Ammonium HydroxideHCID 11378442Potassium cyanateHCID 20514572HCID 20514572, compound

Product 1

HCID 12873988HCID 12873988, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a stirred mixture of 3 parts of imidazo[2,1-b]benzothiazol-6-amine, 16 parts of acetic acid and 32 parts of water is added dropwise a solution of 1.54 parts of potassium cyanate in 32 parts of water (slightly exothermic reaction). Upon completion, stirring is continued overnight at room temperature. The reaction mixture is alkalized with ammonium hydroxide. Upon stirring, the product is precipitated. It is filtered off and dried, yielding 3 parts of N-(2,3-dihydroimidazo[2,1-b]benzothiazol-6-yl)urea; mp. +300° C.

Workup

  1. customslightly exothermic reaction)
  2. stirringUpon stirring
  3. customthe product is precipitated
  4. filtrationIt is filtered off
  5. customdried

Sources & evidence

ORD record
ord-1c5acd4581db4893a2bfa3c092651325
Source dataset
uspto-grants-1981_04
Patent number
US04262004

Reaction notes

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