Water → HCID 12878324, compound

HRID 443954Notes

Reaction equation

HRID 443954 reaction equation
[OH:1][C:2]1([CH3:20])[CH2:8][CH:7]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:18][CH3:19])[CH:12]=2)[O:6][C:4](=[O:5])[CH2:3]1.[C:21](OC(=O)C)(=[O:23])[CH3:22].O>N1C=CC=CC=1>[OH:1][C:2]1([CH3:20])[CH2:8][CH:7]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:21](=[O:23])[CH3:22])=[C:13]([O:18][CH3:19])[CH:12]=2)[O:6][C:4](=[O:5])[CH2:3]1

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 12878322HCID 12878322, compound

Product 1

HCID 12878324HCID 12878324, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 100 mg of 3-hydroxy-3-methyl-7-(p-hydroxy-m-methoxyphenyl)-5-heptanolide in 1 ml of pyridine was added 1 ml of acetic anhydride and the mixture was stirred overnight at room temperature. After completion of the reaction, water was added to the reaction mixture and the mixture was extracted with ethyl acetate. Evaporation of the solvent from the extract yielded the desired compound as a colorless oily substance,

Workup

  1. additionwas added to the reaction mixture
  2. extractionthe mixture was extracted with ethyl acetate
  3. customEvaporation of the solvent from the extract

Sources & evidence

ORD record
ord-9d43504ac0374db485ad4b28db386acf
Source dataset
uspto-grants-1981_04
Patent number
US04262013

Reaction notes

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