Methyl iodide → HCID 848831, compound

HRID 443981Notes

Reaction equation

HRID 443981 reaction equation
[CH3:1][C:2]1[C:3](=[O:14])[NH:4][C:5]2[C:10]([N:11]=1)=[CH:9][C:8]([CH3:12])=[C:7]([CH3:13])[CH:6]=2.CI.[C:17](=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[CH3:17][N:4]1[C:5]2[C:10](=[CH:9][C:8]([CH3:12])=[C:7]([CH3:13])[CH:6]=2)[N:11]=[C:2]([CH3:1])[C:3]1=[O:14]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 10340Sodium CarbonateHCID 2474893,6,7-trimethylquinoxalin-2-ol

Product 1

HCID 848831HCID 848831, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 3,6,7-trimethyl-2(1H)-quinoxalinone (5.0 g., 0.027 mol.), methyl iodide (15 ml.), sodium carbonate (5.0 g., 0.047 mol.) and dimethylformamide (75 ml.) was stirred at room temperature for eighteen hours, then heated at 75°-80° C. for three hours. Removal of the dimethylformamide under reduced pressure and dilution with water gave a brown solid. Crystallization from acetone (Darco) gave light tan needles. (2.85 g., m.p. 164°-166°, 53%)

Workup

  1. temperatureheated at 75°-80° C. for three hours
  2. customRemoval of the dimethylformamide under reduced pressure and dilution with water
  3. customgave a brown solid
  4. customCrystallization from acetone (Darco)
  5. customgave light tan needles

Sources & evidence

ORD record
ord-bdf727b8224d438b9570ccfefa72075d
Source dataset
uspto-grants-1981_04
Patent number
US04262123

Reaction notes

Loading…