Methyl fluorosulfate → 4-Bromo-3-methoxy-2-methylisothiazolium fluorosulfonate

HRID 443991Notes

Reaction equation

HRID 443991 reaction equation
[Br:1][C:2]1[C:3]([O:7][CH3:8])=[N:4][S:5][CH:6]=1.[F:9][S:10]([O:13][CH3:14])(=[O:12])=[O:11]>>[F:9][S:10]([O-:13])(=[O:12])=[O:11].[Br:1][C:2]1[C:3]([O:7][CH3:8])=[N+:4]([CH3:14])[S:5][CH:6]=1

Participants

3

Reactant 2

HCID 9870Methyl fluorosulfateHCID 123939314-Bromo-3-methoxy-1,2-thiazole

Product 1

HCID 867376954-Bromo-3-methoxy-2-methylisothiazolium fluorosulfonateYield 81%

Procedure

4-Bromo-3-methoxyisothiazole (8.0 g, 0.041 mol) and 10 ml of methyl fluorosulfonate were heated at 90° for 45 min. After cooling, the solid was washed with ether to yield 10.3 g (81%) of 4-bromo-3-methoxy-2-methylisothiazolium fluorosulfonate, mp 180°-182° C.

Workup

  1. temperatureAfter cooling
  2. washthe solid was washed with ether

Sources & evidence

ORD record
ord-7bcfc9d5520643e5ac82c9e635ce79b0
Source dataset
uspto-grants-1981_04
Patent number
US04262127

Reaction notes

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