HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromothiophene → HCID 54103588, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromothiophene | HCID 13383 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-Hydroxybutanedinitrile | HCID 21253562 | — |
| Catalyst | copper(I) bromide | HCID 24593 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 54103588 | HCID 54103588 | — |
Reaction Steps
To 157.5 ml anhydrous i-propanol and 17.5 ml DMF, kept under N2 atmosphere, were added while stirring at 20°-35° C. 0.2 mole NaH and then, after the sodium isopropylate had been precipitated, 0.2 mole malonitrile. Within 5 minutes thereafter 0.1 mole copper (I) bromide and 0.1 mole 3-bromothiophene were added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04262129 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-2d7038a0787e46f1945f2d5b91aba505 |
| Source note | uspto-grants-1981_04 |