反应详情

A mixture of diethyl 2-ureidononanedioate (8 g) with diazabicyclononene (DBN) (1.28 g) was heated in a bath at 100° for 1 hour and the reaction mixture was shaken with chloroform and a slight excess of dilute hydrochloric acid. The chloroform phase was separated, washed with water and dried (MgSO4), and the chloroform was evaporated, to give a crystalline residue. The crystals were suspended in ether and collected, to give 5-(6-ethoxycarbonylhexyl) hydantoin, m.p. 110°-110.5° C.

1. temperaturewas heated in a bath at 100° for 1 hour
2. customThe chloroform phase was separated
3. washwashed with water
4. dry with materialdried (MgSO4)
5. customthe chloroform was evaporated
6. customto give a crystalline residue
7. customcollected