Hydrochloric Acid → 5-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran

HRID 444081노트

반응식

HRID 444081 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([Br:9])=[CH:5][C:4]=1[C:10]([CH3:14])([CH3:13])[CH2:11]Cl.Cl.N1C=CC=CC=1.Cl.CCOCC>N1C2C(=CC=CC=2)C=CC=1>[Br:9][C:6]1[CH:7]=[CH:8][C:3]2[O:2][CH2:14][C:10]([CH3:11])([CH3:13])[C:4]=2[CH:5]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 46057784-Bromo-2-(2-chloro-1,1-dimethylethyl)anisoleHCID 10176127Pyridinium chloride

생성물 1

HCID 53235955-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran

시약·촉매·용매 1

HCID 7047Quinoline용매

실험 절차

2-(2-Methoxy-5-bromophenyl)-2-methyl-1-chloropropane (from example 5(a)) (120 g, 0.43 mole) was heated under reflux (163°-9° C.) with pyridine hydrochloride (220 g) in quinoline (220 g) with stirring for 3 hours. Addition to iced dilute hydrochloric acid and isolation through ether gave after distillation 73 g (75%) title product b.p. 62°-4° C. at 0.01 mm Hg.

후처리

  1. customgave
  2. distillationafter distillation 73 g (75%) title product b.p. 62°-4° C. at 0.01 mm Hg

출처 및 근거

ORD 기록
ord-f20c08686ea8421d98b0a1804898bcd5
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263037

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