Acetone → 2-Hydroxy-3,3-dimethyl-2,3-dihydrobenzofuran-5-carbonitrile

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Reaction Steps

The product of Example 45 (2 g) was boiled under reflux in water (5 ml) and acetone (15 ml) for 31/2 hours. The product was then extracted into diethyl ether, the extracted solution then being washed twice with water, dried over sodium sulphate and run down under vacuum to give 1.7 g of crude product. Recrystallisation from toluene gave pure title product (1.3 g), mp 127°-129° C.

Provenance & Evidence