HCID 23464484, compound → HCID 54482241, compound

HRID 444138Notes

Reaction equation

HRID 444138 reaction equation
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([O:15]C)=[O:14])=[CH:12][C:7]=2[S:6](=[O:17])[C:5]2[CH:18]=[CH:19][CH:20]=[CH:21][C:4]=2[NH:3]1>[OH-].[Na+].O1CCCC1>[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([OH:15])=[O:14])=[CH:12][C:7]=2[S:6](=[O:17])[C:5]2[CH:18]=[CH:19][CH:20]=[CH:21][C:4]=2[NH:3]1

Participants

4

Reactant 1

HCID 23464484HCID 23464484, compound

Product 1

HCID 54482241HCID 54482241, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 14798Sodium HydroxideSolvent

Procedure

Stir the oxide from Step A in a mixture of 5 cc of aqueous sodium hydroxide and 10 cc of tetrahydrofuran for 15 minutes. Evaporate the tetrahydrofuran, dilute with water. Filter and acidify the filtrate. Separate the solids by filtration and dry in vacuo at 50° C. Suspend the product in water. Stir overnight, filter and dry at 60° C. to obtain the title product (Yield 605 mg).

Workup

  1. customEvaporate the tetrahydrofuran
  2. additiondilute with water
  3. filtrationFilter
  4. customSeparate the solids
  5. filtrationby filtration
  6. customdry in vacuo at 50° C
  7. filtrationfilter
  8. customdry at 60° C.

Sources & evidence

ORD record
ord-75d1fe81860e41c796a861534a97035f
Source dataset
uspto-grants-1981_04
Patent number
US04263207

Reaction notes

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