反应详情

Stir a mixture of 3.03 gm. (10 mmole) of the ester of Example 15, 2.24 gm. (20 mmole) of 85% aqueous potassium hydroxide, 11 ml. of water, 55 ml. of ethanol and 5.5 ml. of dioxane under nitrogen for 2 hours. Concentrate the reaction mixture to the point of crystallization and dilute with 40 ml. of water. Filter and acidify with acetic acid. Separate the precipitate by filtration and wash with water and dry to obtain the title product (m.p. 304°-306° C.).

1. additiona mixture of 3.03 gm
2. concentrationConcentrate the reaction mixture
3. customto the point of crystallization
4. additiondilute with 40 ml
5. filtrationFilter
6. customSeparate the precipitate
7. filtrationby filtration
8. washwash with water
9. customdry