反应详情

Stir 386 mg (1 mmole) of the ester of Example 19 in a solution of 131.8 mg (2 mmole) of 85% aqueous potassium hydroxide, 1.3 ml of water, 6.5 ml of ethanol and 0.65 ml of dioxane at room temperature under argon for 1 hour. Evaporate to dryness and dissolve the residue in 5 ml of water. Acidify with acetic acid, separate the precipitate by filtration, wash with water and dry. Recrystallize from methanol to obtain the title product (m.p. 200-295 dec).

1. customEvaporate to dryness
2. dissolutiondissolve the residue in 5 ml of water
3. customseparate the precipitate
4. filtrationby filtration
5. washwash with water
6. customdry
7. customRecrystallize from methanol